Advances in solvent-free sample preparation methods for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) of polymers and biomolecules

Advances in solvent-free sample preparation methods for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) of polymers and biomolecules

Blog Article

Matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) is an essential analytical technique for the molecular characterization of biomolecules and synthetic polymers.Its ability to provide comprehensive compositional information not afforded by other techniques, with high sensitivity #N/A and selectivity, is highly influenced by the sample preparation of the material prior to analysis.This review discusses MALDI-MS sample preparation protocols that do not utilize solvents.Such 117 methods provide alternative routes for analyzing insoluble polymeric materials and may also reveal information that is not attainable with solvent-based sample preparation techniques.

Additionally, this review will present relevant surface analysis and imaging results only achievable with solvent-free sample preparation methodologies.